Since October 2001, Margot H. Knight has been president and CEO of United Arts of Central Florida. She currently serves on the executive board of the Orlando Regional Chamber of Commerce, the board for the Orlando/Orange County Convention and Visitors Bureau, and is on the alumni board of James Madison University. In addition, Margot is a member of the Rotary Club of Orlando. The Orlando Business Journal listed her as one of its 100 most influential people in 2002 and named her as finalist for "Women Who Mean Business" in 2005.  In 2004, the Girl Scouts of Citrus Council honored her with a Woman of Distinction award, and she received the Woman's Achievement Award in Arts & Culture in 2006.

Margot enjoyed a brief theatrical career before working in history and the arts. She was the oral historian for the Whitman County, WA Historical Society, director of the Oral History Office at Washington State University, regional coordinator of the Washington Women's Heritage Project, and interim director of the Washington (State) Commission for the Humanities where she designed and raised funds for several oral history projects, including one for pioneering women journalists on behalf of the Washington Press Club Foundation.  

She served as president and CEO of the United Arts Council of Raleigh & Wake County from 1998-2001 and executive director of the Idaho Commission on the Arts from 1990-1997. From 1985-1990, she was assistant director of the National Assembly of State Arts Agencies in Washington, DC.

She has served on the executive committees of the Greater Raleigh Chamber of Commerce, Western States Arts Federation, National Assembly of State Arts Agencies, and the Idaho Rural Partnership, which she chaired in 1996. In 1997, the Idaho Commission on Hispanic Affairs honored her for her contributions to the Hispanic community.